From Politico's John Bresnahan:
Following the victory by Democrat Travis Childers in tonight's special election, National Republican Congressional Committee Chairman Tom Cole (Okla.) issued what can only be called a declaration of surrender.... [The] statement is an admission by Cole that he does not now how House Republicans can win in November as a group, so each member better protect himself or herself. To his credit, Cole has been warning his members that they need to run as outsiders this fall, but beyond that general admonition, the Oklahoma Republican can't show them a path to victory. It's an extraordinary statement by the head of a national campaign committee, but it is not one that's going to inspire any warm feelings from his GOP colleagues.
Cole's statement--and Bresnahan's analysis--are here.