Meet the Americans who are exploring new frontiers in hallucinogenic research through a nascent technology known as extended-state DMT.

U.S. lawmakers unveiled a sweeping $1.7 trillion government spending bill. Still, they managed to exclude some popular provisions.

It becomes the second state after Oregon to give the OK to psychedelics.

Politicians and lawmakers are equating large-scale fentanyl seizures with progress in combating the drug’s epidemic, forgetting the lessons from the age of crack.

The GOP is ramping up its rhetoric about Biden, the border, kids, and overdoses.

The U.S. has treatments to help people dealing with opioid addictions but throws up hurdles to access.

The District is used to Republicans thwarting its independence. But local politicians are appalled that Democrats are now doing the same.

Right-wingers dusted off their 1980s playbook to demonize a valid harm-reduction technique—and Democrats shamefully caved to them.

Biden needs to ditch his old-fashioned ideas about marijuana and realize that legalization is a winning bipartisan issue—something he desperately needs in 2022.

Federal drug policy needs a major overhaul, but Rahul Gupta has a record of making harmful compromises.

Both coffee and opium come from plants. Why embrace one and not the other?

An internet huckster got rich selling a sex enhancement supplement named Stiff Nights. Then the FDA sampled his wares.

The line between legal pharmaceuticals and illegal drugs has less to do with science than with race, class, and gender.

They seeded medical breakthroughs and emerging markets. Now expunge their criminal records and let them go legit.

Traditional treatments often take place in expensive facilities, demand total abstinence, and rely on punitive methods of control. A harm reduction model turns all of that on its head.

How the seizure of Europe's largest heroin shipment created bloody fallout throughout the world—and sparked still-raging political corruption scandals in Turkey, Greece, and the Middle East

“Any gains we made in funding for health departments, syringe exchanges, naloxone distribution—it’s all at risk.”

Netflix’s documentary captures the newfound acceptability of mind-altering substances.

From alcohol to amphetamines, a new book shows intimate links between the policing of substances and the waging of war.

The progressive prosecutor wants to fight gun violence with a light touch. His critics say he’s crazy. His defenders say he’s onto something.