Both coffee and opium come from plants. Why embrace one and not the other?

They seeded medical breakthroughs and emerging markets. Now expunge their criminal records and let them go legit.

Traditional treatments often take place in expensive facilities, demand total abstinence, and rely on punitive methods of control. A harm reduction model turns all of that on its head.

Sizing up the commercial and therapeutic prospects for the psychedelic revival

From alcohol to amphetamines, a new book shows intimate links between the policing of substances and the waging of war.

The paper's otherwise stellar investigative journalism accidentally exposes the failed Beltway consensus.

When Chad Baker died from a lethal combination of cocaine and heroin, prosecutors charged Tommy Kosto, his friend and fellow drug user, with killing him—a tactic from the Reagan-era war on drugs that is gaining popularity around the country and making today's opioid crisis even worse.

America came close to legalizing marijuana in the 1970s. What went wrong?

Theories abound about the suspicious timing of the drug lord’s extradition. But the real story is the information El Chapo might spill.

Why did "Queen of the South" kill its best character?

The Netflix series prides itself on telling hard truths. But it really doesn't have a clue.

The new president of the Philippines is behind an anti-drug campaign that has claimed nearly 2,500 lives. And he's just getting started.